Hemoglobin Titusville: a rare low oxygen affinity hemoglobinopathy
نویسندگان
چکیده
The relevance of this case lies in the extensive diagnostic workup that can be avoided with proper laboratory evaluation of relatively unsophisticated tests.
منابع مشابه
Polycythemia Associatedwith a Hemoglobinopathy 815 a - N ( Bart ' S ) I a - Ho 2 a - Ches I a - Gssg Aa B . . . S - C Agr Starch Gel Hemoglobin Chesapeake
The efficiency of hemoglobin as an oxygencarrying substance is dependent upon certain features of its molecular configuration. The functional integrity of the molecule depends not only on spatial relationships between the heme and globin moieties, but on interrelations between the four globin chains (1, 2). The functional significance of portions of the molecule can be investigated by a study o...
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Hemoglobin is a tetrameric oxygen transport protein in animal bodies. However, there is a paucity of information regarding differences between alpha and beta subunits of hemoglobin in terms of oxygen affinity. The sequential model of Koshland, Nemthy and Filmer (KNF model) has attributed similar affinities to both alpha and beta subunits. The main purpose of the present study is to construct a ...
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In 1954 a then 31-yr-old male was found to have erythrocytosis. Over the ensuing decade he received 72 mCi32P. In 1964 his daughters were found to have erythrocytosis. Further investigation led to the discovery of hemoglobin Yakima, a variant with high oxygen affinity. He received no further therapy and was well until 1975, when he developed the preleukemic syndrome. Within 12 mo. he developed ...
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In 1954 a then 31 -yr-old male was found to have erythrocytosis. Over the ensuing decade he received 72 mCi 32P. In 1964 his daughters were found to have erythrocytosis. Further investigation led to the discovery of hemoglobin Yakima, a variant with high oxygen affinity. He received no further therapy and was well until 1975, when he developed the preleu. kemic syndrome. Within 12 mo he develop...
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